).
Summary
Fibromyalgia is a syndrome characterized by widespread
pain, fatigue and sleep disorders, beside other symptoms.
Its patophysiology remains unkown, though there are
many hypothesis considering its origin.
Initially, will be discussed the theory of somatization,
based on the occurrence of comorbity with psychiatric
and psychological disorders, like traumas and childhood
abuse and pos-traumatic stress syndrome.
It also be discoursed about the neurological hypothesis,
based on alterations of blood flow and cerebral activation
found on imaging diagnosis methods the neuroendocrine
theory, born from the alteration of hormones and
neurotransmitters found on these patients the inflammatory
hypothesis, supported by altered levels of cytokines
in the plasma and skin biopsies and, at last, the alterations
of NMDA receptor, important in the pain process.
Furthermore, the importance of these hypotheses will
be shown as therapeutic basis.