The nonsteroidal anti-inflammatory drugs (NSAIDs) have been used to treat signs and symptoms of inflammation for a century. Its mechanism of action is basically the inhibition of prostaglandins synthesis, important mediators of inflammatory response. The NSAIDs in current use inhibit both constitutive (COX-1) and inducible (COX-
2) cyclooxigenase. Besides the anti-inflammatory action, the NSAIDs also decrease pain, suppress fever and decrease platelet adhesiveness. They differ in terms of half-life, dose, peak of action, potential adverse effects and cost. Its use is associated with several adverse effects, including renal hepatic and gastrointestinal damage, hematological, skin, gestational, coagulation and others.
Desenvolvido por Node1 Interactive – 2001