An aged and bad preserved skin may not shortens life, but certainly affects quality of life. The psychological impact of the skin condition is huge mostly because it is the principal organ of non oral communication. The effects of aging and menopause on the skin condition elect this organ as a biological herald well characterized in the study of the senescent skin. The skin is without doubt an important end organ of the sexual steroids. Topical and oral estrogens can preserve skin width and increase the collagen and glucosaminoglycans contents. It can be concluded that in menopause it is necessary to apply the concept of cosmetic treatment that enhances the personal glamour and express a healthy life stile, and at long term a positive attitude of the woman in relationship with her self image, achieving as end result a better quality of life.