Summary

The author presents the estrogens central role in the biological female rithms (menstruation, menopause), that modification can develop cyclic mood disturbances suggesting an antidepressant action of estrogen during the post-menopause period.

The hormonal replacement therapy seems to show a beneficial effect on mood and memory and protect women from psychiatric disturbances such as depression that will develop further, showing also a prophylactic effect against Alzheimer disease.

The more intense symptomatology cases in the peri-menopause, besides estrogen therapy may need antidepressant standard therapy.