Continuous hormonal treatment is the standard procedure for stage T3-4 NX M+ adenocarcinoma of the prostate. Experimental studies have shown that intermittent (IHT) increases the response period to the treatment. However, few clinical studies have been carried out until now. In this study we compare the effects of continuous and intermittent hormonal treatment in patients with adenocarcinoma of the prostate. In the period studied, IHT was as effective as continuous hormonal treatment but afforded a better quality of life and 87% of the patients were potent during the intervals between the cycles.